ParkinsonV1, Main, Corpus, bibRecord, 002F71

Clinicopathological analysis of dementia disorders in the elderly

Identifieur interne : 002F71 ( Main/Corpus ); précédent : 002F70; suivant : 002F72

Clinicopathological analysis of dementia disorders in the elderly

Auteurs : K. Jellinger ; W. Danielczyk ; P. Fischer ; E. Gabriel

Source :

Journal of the Neurological Sciences [ 0022-510X ] ; 1989.

RBID : ISTEX:857B0E0715A2664E54B68C4DE771639456748176

English descriptors

KwdEn :
- Alzheimer disease, Clinicopathological correlations, Dementia, Mixed type of dementia, Vascular dementia.

Abstract

The relative incidence of the major types of dementia disorders and the agreement rates between clinical and pathological diagnosis were analysed in consecutive autopsy series of 675 demented subjects from 3 hospitals (mean age 79.5 years, SD 9.6). Clinical assessment followed the DSM-III and ICD-9-NA criteria and NINCDS/ADRDA criteria for probable Alzheimer disease (AD) (McKhann et al. 1984), histological criteria for the diagnosis of AD those of the NIH/AARP Work Group (Khachaturian 1985) using a 4-degree rating scale for plaques and tangles in neocortex and hippocampus (Morris et al. 1988), and the criteria by Tierney et al. (1988) for ‘pure’ AD. Vascular dementia (MID) and other disorders were diagnosed according to current pathologic criteria. Clinical diagnosis of AD/SDAT was made in 59.2%, of MID in 21.7%, of mixed AD+MID in 3.1%, and of Parkinson's disease (PD) and other disorders in 16%. At autopsy, 76.7% fulfilled histological criteria for AD/SDAT, but only 60% were ‘pure’ forms, while 8.2% had additional features of PD and 7.9% coexisting vascular lesions indicating mixed SDAT+MID. 15.7% were MID with no or very little AD pathology, 7.4% other CNS disorders. 0.3% of the brains showed no abnormality beyond age-related changes. AD/SDAT had its highest incidence in a psychiatric population, MID and PD+SDAT in general and geriatric hospital cohorts. The overall coincidence rates for clinical and pathological diagnosis of AD/SDAT were 85.2%, for MIX and MID 60.5–61.9%, but only 51% for PD-PD/AD. These data and the results of other recent studies emphasize the need for more appropriate clinical and pathological criteria in the diagnosis of the dementias.

Url:

https://api.istex.fr/document/857B0E0715A2664E54B68C4DE771639456748176/fulltext/pdf

DOI: 10.1016/0022-510X(90)90072-U

Links to Exploration step

ISTEX:857B0E0715A2664E54B68C4DE771639456748176

Le document en format XML

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<abstract xml:lang="en"><p>The relative incidence of the major types of dementia disorders and the agreement rates between clinical and pathological diagnosis were analysed in consecutive autopsy series of 675 demented subjects from 3 hospitals (mean age 79.5 years, SD 9.6). Clinical assessment followed the DSM-III and ICD-9-NA criteria and NINCDS/ADRDA criteria for probable Alzheimer disease (AD) (McKhann et al. 1984), histological criteria for the diagnosis of AD those of the NIH/AARP Work Group (Khachaturian 1985) using a 4-degree rating scale for plaques and tangles in neocortex and hippocampus (Morris et al. 1988), and the criteria by Tierney et al. (1988) for ‘pure’ AD. Vascular dementia (MID) and other disorders were diagnosed according to current pathologic criteria. Clinical diagnosis of AD/SDAT was made in 59.2%, of MID in 21.7%, of mixed AD+MID in 3.1%, and of Parkinson's disease (PD) and other disorders in 16%. At autopsy, 76.7% fulfilled histological criteria for AD/SDAT, but only 60% were ‘pure’ forms, while 8.2% had additional features of PD and 7.9% coexisting vascular lesions indicating mixed SDAT+MID. 15.7% were MID with no or very little AD pathology, 7.4% other CNS disorders. 0.3% of the brains showed no abnormality beyond age-related changes. AD/SDAT had its highest incidence in a psychiatric population, MID and PD+SDAT in general and geriatric hospital cohorts. The overall coincidence rates for clinical and pathological diagnosis of AD/SDAT were 85.2%, for MIX and MID 60.5–61.9%, but only 51% for PD-PD/AD. These data and the results of other recent studies emphasize the need for more appropriate clinical and pathological criteria in the diagnosis of the dementias.</p>
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<head><ce:title>Clinicopathological analysis of dementia disorders in the elderly</ce:title>
<ce:author-group><ce:author><ce:given-name>K.</ce:given-name>
<ce:surname>Jellinger</ce:surname>
<ce:cross-ref refid="cor1"><ce:sup>5</ce:sup>
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<ce:author><ce:given-name>E.</ce:given-name>
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<ce:textfn>Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Vienna Austria</ce:textfn>
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<ce:textfn>Department of Neurology, Lainz Geriatric Hospital, Vienna Austria</ce:textfn>
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<ce:affiliation id="aff3"><ce:label>3</ce:label>
<ce:textfn>Institute of Neurology, Vienna University School of Medicine, Vienna Austria</ce:textfn>
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<ce:text>Correspondence to: Prof. Dr. K. Jellinger, Ludwig Boltzmann-Institut für klinische Neurobiologie, Krankenhaus Wien-Lainz, Wolkersbergenstrasse 1, A-1130 Wien, Austria.</ce:text>
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<ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>The relative incidence of the major types of dementia disorders and the agreement rates between clinical and pathological diagnosis were analysed in consecutive autopsy series of 675 demented subjects from 3 hospitals (mean age 79.5 years, SD 9.6). Clinical assessment followed the DSM-III and ICD-9-NA criteria and NINCDS/ADRDA criteria for probable Alzheimer disease (AD) (McKhann et al. 1984), histological criteria for the diagnosis of AD those of the NIH/AARP Work Group (Khachaturian 1985) using a 4-degree rating scale for plaques and tangles in neocortex and hippocampus (Morris et al. 1988), and the criteria by Tierney et al. (1988) for ‘pure’ AD. Vascular dementia (MID) and other disorders were diagnosed according to current pathologic criteria. Clinical diagnosis of AD/SDAT was made in 59.2%, of MID in 21.7%, of mixed AD+MID in 3.1%, and of Parkinson's disease (PD) and other disorders in 16%. At autopsy, 76.7% fulfilled histological criteria for AD/SDAT, but only 60% were ‘pure’ forms, while 8.2% had additional features of PD and 7.9% coexisting vascular lesions indicating mixed SDAT+MID. 15.7% were MID with no or very little AD pathology, 7.4% other CNS disorders. 0.3% of the brains showed no abnormality beyond age-related changes. AD/SDAT had its highest incidence in a psychiatric population, MID and PD+SDAT in general and geriatric hospital cohorts. The overall coincidence rates for clinical and pathological diagnosis of AD/SDAT were 85.2%, for MIX and MID 60.5–61.9%, but only 51% for PD-PD/AD. These data and the results of other recent studies emphasize the need for more appropriate clinical and pathological criteria in the diagnosis of the dementias.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords class="keyword" xml:lang="en"><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>Dementia</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Alzheimer disease</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Vascular dementia</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Mixed type of dementia</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Clinicopathological correlations</ce:text>
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</head>
<tail><ce:bibliography><ce:section-title>References</ce:section-title>
<ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>Alafuzoff et al., 1987</ce:label>
<sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Alafuzoff</ce:surname>
<ce:given-name>I.</ce:given-name>
</sb:author>
<sb:author><ce:surname>Iqbal</ce:surname>
<ce:given-name>K.</ce:given-name>
</sb:author>
<sb:author><ce:surname>Frieden</ce:surname>
<ce:given-name>H.</ce:given-name>
</sb:author>
<sb:author><ce:surname>Adolfson</ce:surname>
<ce:given-name>R.</ce:given-name>
</sb:author>
<sb:author><ce:surname>Winblad</ce:surname>
<ce:given-name>B.</ce:given-name>
</sb:author>
</sb:authors>
<sb:title><sb:maintitle>Histopathological criteria for progressive dementia disorders</sb:maintitle>
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</sb:title>
<sb:book-series><sb:series><sb:title><sb:maintitle>MNH/MEP/87.1</sb:maintitle>
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<sb:location>Geneva</sb:location>
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<mods version="3.6"><titleInfo lang="en"><title>Clinicopathological analysis of dementia disorders in the elderly</title>
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<titleInfo type="alternative" lang="en" contentType="CDATA"><title>Clinicopathological analysis of dementia disorders in the elderly</title>
</titleInfo>
<name type="personal"><namePart type="given">K.</namePart>
<namePart type="family">Jellinger</namePart>
<affiliation>Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Vienna Austria</affiliation>
<description>Correspondence to: Prof. Dr. K. Jellinger, Ludwig Boltzmann-Institut für klinische Neurobiologie, Krankenhaus Wien-Lainz, Wolkersbergenstrasse 1, A-1130 Wien, Austria.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
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<name type="personal"><namePart type="given">W.</namePart>
<namePart type="family">Danielczyk</namePart>
<affiliation>Department of Neurology, Lainz Geriatric Hospital, Vienna Austria</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">P.</namePart>
<namePart type="family">Fischer</namePart>
<affiliation>Institute of Neurology, Vienna University School of Medicine, Vienna Austria</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E.</namePart>
<namePart type="family">Gabriel</namePart>
<affiliation>Psychiatric Hospital Baumgartnerhöhe, Vienna Austria</affiliation>
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<dateValid encoding="w3cdtf">1989-10-16</dateValid>
<dateModified encoding="w3cdtf">1989-10-09</dateModified>
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<abstract lang="en">The relative incidence of the major types of dementia disorders and the agreement rates between clinical and pathological diagnosis were analysed in consecutive autopsy series of 675 demented subjects from 3 hospitals (mean age 79.5 years, SD 9.6). Clinical assessment followed the DSM-III and ICD-9-NA criteria and NINCDS/ADRDA criteria for probable Alzheimer disease (AD) (McKhann et al. 1984), histological criteria for the diagnosis of AD those of the NIH/AARP Work Group (Khachaturian 1985) using a 4-degree rating scale for plaques and tangles in neocortex and hippocampus (Morris et al. 1988), and the criteria by Tierney et al. (1988) for ‘pure’ AD. Vascular dementia (MID) and other disorders were diagnosed according to current pathologic criteria. Clinical diagnosis of AD/SDAT was made in 59.2%, of MID in 21.7%, of mixed AD+MID in 3.1%, and of Parkinson's disease (PD) and other disorders in 16%. At autopsy, 76.7% fulfilled histological criteria for AD/SDAT, but only 60% were ‘pure’ forms, while 8.2% had additional features of PD and 7.9% coexisting vascular lesions indicating mixed SDAT+MID. 15.7% were MID with no or very little AD pathology, 7.4% other CNS disorders. 0.3% of the brains showed no abnormality beyond age-related changes. AD/SDAT had its highest incidence in a psychiatric population, MID and PD+SDAT in general and geriatric hospital cohorts. The overall coincidence rates for clinical and pathological diagnosis of AD/SDAT were 85.2%, for MIX and MID 60.5–61.9%, but only 51% for PD-PD/AD. These data and the results of other recent studies emphasize the need for more appropriate clinical and pathological criteria in the diagnosis of the dementias.</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>Dementia</topic>
<topic>Alzheimer disease</topic>
<topic>Vascular dementia</topic>
<topic>Mixed type of dementia</topic>
<topic>Clinicopathological correlations</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Journal of the Neurological Sciences</title>
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<titleInfo type="abbreviated"><title>JNS</title>
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<genre type="Journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">199003</dateIssued>
</originInfo>
<identifier type="ISSN">0022-510X</identifier>
<identifier type="PII">S0022-510X(00)X0381-4</identifier>
<part><detail type="volume"><number>95</number>
<caption>vol.</caption>
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<detail type="issue"><number>3</number>
<caption>no.</caption>
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<extent unit="issue pages"><start>239</start>
<end>359</end>
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<extent unit="pages"><start>239</start>
<end>258</end>
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</part>
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<identifier type="istex">857B0E0715A2664E54B68C4DE771639456748176</identifier>
<identifier type="DOI">10.1016/0022-510X(90)90072-U</identifier>
<identifier type="PII">0022-510X(90)90072-U</identifier>
<identifier type="ArticleID">9090072U</identifier>
<accessCondition type="use and reproduction" contentType="">© 1990Elsevier Science Publishers B.V. (Biomedical Division), Amsterdam All rights reserved</accessCondition>
<recordInfo><recordContentSource>ELSEVIER</recordContentSource>
<recordOrigin>Elsevier Science Publishers B.V. (Biomedical Division), Amsterdam All rights reserved, ©1990</recordOrigin>
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Clinicopathological analysis of dementia disorders in the elderly

Clinicopathological analysis of dementia disorders in the elderly

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